I usually can't wear mineral makeup, because sunscreens with titanium/zinc make me break out for some reason. You'd think that a powder form would be different, but even loose/powder foundation with a lot of titanium dioxide in it does. I think sometimes it's used for SPF and other times just for pigment. I don't have any burning or irritation, just huge cystic pimples after a day or two. I can sometimes avoid it if I wash my face extremely thoroughly at night, though. I have to first use an oil cleanser to melt all the makeup off, and then wash my face again with a regular cleanser.
I suggest applying with a latex sponge instead. all that buffing pushes TD or ZO into the pores causing breakouts.